Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

Journal article

Marco Vicari, R. Mirzazadeh, A. Nilsson, Reza Shariatgorji, Patrik Bjärterot, L. Larsson, Hower Lee, M. Nilsson, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, P. Svenningsson, P. Andrén, J. Lundeberg
bioRxiv, 2023

Semantic Scholar DOI

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APA Click to copy
Vicari, M., Mirzazadeh, R., Nilsson, A., Shariatgorji, R., Bjärterot, P., Larsson, L., … Lundeberg, J. (2023). Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues. BioRxiv.

Chicago/Turabian Click to copy
Vicari, Marco, R. Mirzazadeh, A. Nilsson, Reza Shariatgorji, Patrik Bjärterot, L. Larsson, Hower Lee, et al. “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues.” bioRxiv (2023).

MLA Click to copy
Vicari, Marco, et al. “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues.” BioRxiv, 2023.

BibTeX Click to copy

@article{marco2023a,
  title = {Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues},
  year = {2023},
  journal = {bioRxiv},
  author = {Vicari, Marco and Mirzazadeh, R. and Nilsson, A. and Shariatgorji, Reza and Bjärterot, Patrik and Larsson, L. and Lee, Hower and Nilsson, M. and Foyer, Julia and Ekvall, Markus and Czarnewski, Paulo and Zhang, Xiaoqun and Svenningsson, P. and Andrén, P. and Lundeberg, J.}
}

Abstract

We present a spatial omics approach that merges and expands the capabilities of independently performed in situ assays on a single tissue section. Our spatial multimodal analysis combines histology, mass spectrometry imaging, and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular weight metabolites across tissue regions. We demonstrate the potential of our method using murine and human brain samples in the context of dopamine and Parkinson’s disease.